abstract |
8 - CARBAMOYL - 2 - (2, 3 - DISUBSTITUTED PYRID - 6 - YL) -1 , 2 , 3, 4 - TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y' is phenylene or heteroarylene; L' is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; ZI is C(O)OR 9, C(O)NR 0R" , C(O)R", NR1 0C(O)R", etc. |