| abstract |
1: \rbr\Interwoven\NRPortbl\DCC\RBR\14813874_ldocx-20 06/2017 Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of 5 diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in 10 combination with another therapeutic agent. WO 2014/186313 PCT/US2014/037767 Figure 1. H-NMR Spectrum of Compound 1 :BRUKEMR ----- -- -- ------- --- n pt 13 12 11 10 9 a 7 6 5 4 3 2 1 ppm |