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filingDate 2017-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AU-2017203769-B2
titleOfInvention Composition and method for inner ear sensory hair cell regeneration and replacement
abstract A composition and method for replacement and regeneration of hair cells of the inner ear is provided. The composition comprises an active agent in an amount effective to decrease Hes 1 gene expression in a tissue of the inner ear. The active agent can be short interfering RNA (siRNA) molecules encapsulated in a biodegradable nanoparticle. The method involves administering a solution to the inner ear where the solution contains an active agent in an amount effective to decrease Hes 1 gene expression.
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