abstract |
Abstract Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates 5 of an active agent such as a therapeutic; prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the 10 conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases. 8611910_1 (GHMatters) P100074.AU.1 17/01/17 -1- Compound in nanoparticle c 100 0 -A- Compound dosed as free drug c L)E z 0.001 0 5 10 15 20 Time (h) |