http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016259284-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65be1a55178c9cb9b4fc6110f09632d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate | 2016-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73befd932f7faadf4630248007141668 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b34fce7cb7147847ad94066345722f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d3c377d6813c9b86ace8858274f2dd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6af0a48d111a3859d2f07c288acb3385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cf25a808d24ed1cfc139d8fdf9a7445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52766dc6f402ae322fd38d6eb943ed36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3eac90266177c787c33d68f89f8ca66c |
publicationDate | 2016-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | AU-2016259284-A1 |
titleOfInvention | Humanized M-CSF mice |
abstract | Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; inin vivoscreens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivoscreens for agents that are toxic to hematopoietic cells; in in vivoscreens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc. |
priorityDate | 2011-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 414.