| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b755982699e3ea5199d569ee5f5344c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3abd52d81588be02fd36e8a09a1d866 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate |
2016-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cece270013f87c741c9096cf58b9690
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf93c1b88f5b0045582c7331b52a10a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b278b8766f2d1596080c486ce7188ddd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07c0ac6657b7c4e6c4d7d5b4ddedc302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_945a12b0e01ddcc694ac8b5bf6d3b7c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68f9cfd783f28a81adae436ef8c0e037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88d80d3e822be4d290903d648ebc75a3 |
| publicationDate |
2016-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2016210677-A1 |
| titleOfInvention |
Methods of Synthesis of Benzazepine Derivatives |
| abstract |
The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yields than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry. (i)N 'D. (ii) Br NO2 Br NO2 HF3 Br N02 Ph 3 P~ CN Ph3( OEt Ph3P OEt (iv) ZNN OEt Br NO CN HOEt (v)(v N ,z (v ii) _ _ _ _ _ _ ) OBOr" O t BrO ( Br O Br N O HGO N NHBoc NHBoc NH2 HF9 HF8 (viii) OH ONnPr " O y~r 'OH P nPr (ix)N N NHBoc Br N- NHBoc 0 HG3 T 0 /nPr nPr F' NH2 Fig. 1 |
| priorityDate |
2008-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |