http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016203944-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5dd388a5130b0bdede0fdfc6c2af6ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f79749e86afce9444a364ab60ca3584 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-36 |
| filingDate | 2016-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04a0796fb77eb1e3f356628c92f328a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83e8ff668a6cd0ce8d82fb515c69a7fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5f3355d8da1d5f150f9242a5016bdb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c46683d891bbbf41d06c099b4b95646a |
| publicationDate | 2016-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016203944-A1 |
| titleOfInvention | Anti-factor xi monoclonal antibodies and methods of use thereof |
| abstract | The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain 5 of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives ofthe monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI 10 monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods ofthe invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or 15 treating an acute inflammatory reaction. Methods for making an anti-factor XI monoclonal antibody, or epitope-binding fragments, variants, or derivatives thereof, are also provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2800719-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110325550-A |
| priorityDate | 2007-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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