abstract |
H:\ft\interwoven\NRPortbl\DCC\FMT\I 0258723_l.docx-3/06/2016 This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties. |