abstract |
H:\RBR\jntenvvn\RPo,,HI\DCC\RBRU0058322_Ldox-28/0I 20J6 The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib. |