http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102309-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a38335d7eddda25a301388f254a7ad2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52 |
| filingDate | 2016-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acee4db679acd87d7daf4b462e28170d |
| publicationDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102309-A4 |
| titleOfInvention | Furtrethonium iodide pharmaceutical intermediate 2- dimethylamino-methylfuran synthesis method |
| abstract | Furtrethonium iodide pharmaceutical intermediate 2 dimethylamino-methylfuran synthesis method, comprising the following steps: equipped with a stirrer, a thermometer and a dropping funnel , the reaction vessel was added 1.6mol dimethylamine methanol solution (3), 500ml oxalic acid solution, 1.8 mol alumina, 2.1-2.6mol 2-furan dimethanol solution (2), controlling the stirring speed 130-170rpm, raised the solution temperature to 120-128 0C, continued the reaction for 5-8h, reducing the temperature of the solution to 90--96 0C, refluxed for 2-3h, added 130ml phosphoric acid solution after cooling, increased solution temperature to 60--66 0C, stirred for 90-130 min, added 300ml sodium sulfite solution, continued reaction for 80-110min, the temperature of the solution is reduced to 10 - 15 0C, added 1 10ml potassium hydrogen sulfite solution, allowed to stand for 3-5h, the solution appeared layer, separated the oil, the aqueous layer was extracted for 5-8 times with nitromethane solution, combined oil layer, dehydrated with dehydration agent, vacuum distillation, collecting fractions of 110--116 0C, recrystallized from toluene solution, got 2- dimethylamino-methylfuran . |
| priorityDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.