http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102301-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a38335d7eddda25a301388f254a7ad2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C17-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C21-14 |
| filingDate | 2016-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acee4db679acd87d7daf4b462e28170d |
| publicationDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102301-A4 |
| titleOfInvention | Pancuronium pharmaceutical intermediate 2-bromo-propene synthesis method |
| abstract | Pancuronium pharmaceutical intermediate 2-bromo-propene synthesis method, comprising the following steps: equipped with a stirrer, a thermometer and a dropping funnel, the reaction vessel was added 1.3mol 2-nitro-phenol solution (3), 1.7mol sodium sulfite solution, 1.7-2.1mol 1-bromo-2-aminopropane (2), controlling the stirring speed 130-170rpm, raised the solution temperature to 60--65 0C, maintained at reflux for 3-5h, temperature was lowered to 40--450C, added 500ml acetonitrile solution, reaction was continued for 70-90min, the temperature of the solution is reduced to 10--16 0C, solid, suction filtered, washed with salt solution, washed with nitro methane solution, precipitate under reduced pressure distillation, collecting fractions 30-35 0C, recrystallized in p-xylene solution, got crystals of 2-bromo-propene. |
| priorityDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.