http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102261-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_317f207d800e7d0d06f670d94cc9c126 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00 |
| filingDate | 2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a18cc5cc94a7dbef071858a27623e8d |
| publicationDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102261-A4 |
| titleOfInvention | Pyrimethamine drug intermediates chloro benzonitrile synthesis method |
| abstract | Pyrimethamine drug intermediates chloro benzonitrile synthesis method , comprising the following steps: equipped with a stirrer, a thermometer, a reflux condenser and a dropping funnel, the reaction vessel was added 1.3mol p-chlorobenzyl (2), 0.56 mol stannous chloride, controlling the stirring speed 130-160rpm, elevated solution temperature to 90-95 C, slowly added 1.5-1.7mol cyanamide (3), controlled dropping time in 1-2 h, continued the stirring 4-5h, reducing the temperature of the solution to 10 - 15 C, adding 230ml sodium chloride solution, separated the water layer, the oil layer was washed with brine solution, washed with acetonitrile solution, vacuum distillation, fraction is recrystallized from ethyl acetate solution, got chloro benzonitrile . |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.