http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102260-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_317f207d800e7d0d06f670d94cc9c126 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a18cc5cc94a7dbef071858a27623e8d |
| publicationDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102260-A4 |
| titleOfInvention | Methimidol pharmaceutical intermediate 1- (β- hydroxyethyl) -2-methylimidazole synthesis method |
| abstract | Methimidol pharmaceutical intermediate 1- (0- hydroxyethyl) -2-methylimidazole synthesis method , comprising the following steps: (i) equipped with a stirrer, thermometer and reflux condenser, the reaction vessel was added 1.3mol 2-methylimidazole (2), 1.5-1.7mol amine alcohols, 200ml nitroethane, raised the solution temperature to 70 - 75 C, reflux for 9-10 h, reducing the temperature of the solution to 50--55 C, standing layered and got out lower liquid, dissolved in 1.3-1.6L propionitrile solution, reducing the solution temperature to 13 - 15 C, added 130ml oxalic acid solution, reducing the solution temperature to 2--4 C, suction filtered, washed with 130ml cyclohexane solution, and recrystallized from acetonitrile solution, decolorized with molecular sieve, controlling the stirring rate 90-110rpm, after 2-3h , the precipitated solid was washed with salt solution, washed with isopropanol solution, dehydrated with dehydrating agent, drying at 70 - 75 C, got 1- ( hydroxyethyl) -2-methylimidazole. |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.