http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102234-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_317f207d800e7d0d06f670d94cc9c126 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-45 |
| filingDate | 2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28661036e85d92406bf9403910cb09ca |
| publicationDate | 2017-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102234-A4 |
| titleOfInvention | Naproxen drug intermediates 6-methoxy-2-propionyl naphthalene synthesis method |
| abstract | Naproxen drug intermediates 6-methoxy-2-propionyl naphthalene synthesis method, comprising the following steps: equipped with a stirrer, a reflux condenser, a thermometer and a dropping funnel , the reaction vessel was added 300-310ml triethylamine solution, 0.61-0.65mol stannous chloride, controlling the stirring speed 160-190rpm, the temperature of the solution is reduced to 3 - 5 0C, added slowly 0.5-0.65molp -naphthyl methyl ether (2), dropping 0.47 mol propionamide solution (3), controlled drop time in 50-80min, maintaining the reaction 8-9h, the solution temperature increased to 17-19 0C, standing 20-22h, the reaction solution was poured into 1.8L sodium bisulfite solution, controlled the solution temperature at 2--5 0C, steam distillation, until triethylamine completely steamed up, controlling the stirring speed 110-130rpm, allow the solution to cool, solidify oil, suction, washed with saline solution, dehydrated with dehydrating agent, recrystallized in cyclohexane solution, got yellow solid 6-methoxy-2-propionyl naphthalene. |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.