http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102232-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd20b094ffaae58b31b1869dfad95d32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 |
| filingDate | 2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8c41faebac82a24549c3dcf072af1e0 |
| publicationDate | 2017-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102232-A4 |
| titleOfInvention | Cis-4-(2-methyl-p-tert-amyl-phenylpropionyl)-2,6-dimethyl- morpholine synthesis method |
| abstract | Cis-4-(2-methyl-p-tert-amyl-phenylpropionyl)-2,6-dimethyl-morpho line synthesis method, comprising the following steps: (i) equipped with a stirrer, a reflux condenser, a reaction vessel was added 0.5mol 2-methyl-3-p-tert-amyl-phenylpropionic acid (2), 400ml propionitrile, 300ml potassium bromide solution, the solution was heated to 80-85 C, refluxing for 4-4.5h, vacuum distillation, propionitrile was recycled, got 2-methyl-3-p-tert-amyl-phenyl propionyl bromide; (ii) 260ml nitromethane was added in the oily component got step (i), control the temperature of the solution at 30-35 C, and 0.6-0.7mol cis-2-6- dimethyl morpholine was added dropwise, the dropping time was controlled in 50-80min, control the stirring rate at 200-230rpm, stirring time was within 5-6h, vacuum distillation, the solvent was recovered, got yellow-green oily component, diluting by adding potassium bromide solution and extracted 5-8 times with nitroethane, dehydrated with anhydrous potassium carbonate, evaporated until there is no nitroethane left, eluted with 4-methyl-2-pentanone, the eluent was evaporated, ultimately got a colorless oily liquid cis-4-(2-methyl-3-p tert-amyl phenylpropionyl) -2,6-dimethyl morpholine. |
| priorityDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.