http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102162-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd20b094ffaae58b31b1869dfad95d32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B43-06 |
| filingDate | 2016-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d9d195afaf931dbed1c2590063dfee1 |
| publicationDate | 2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102162-A4 |
| titleOfInvention | Tocainide drug intermediates α-bromo-propionyl-2,6-dimethylaniline synthesis method |
| abstract | Tocainide drug internediatesa-bromo-propionyl-2,6-dimethylaniline synthesis method, comprising the following steps: equipped with a stirrer, a thermometer, a reflux condenser, a dropping funnel, a reaction vessel was added with 1.55 mol 2,6-dimethylaniline, 2.4-2.6L isopropanol, controlling the stirring speed at 130-150rpm, heating the temperature of solution to 85--90'C, maintaining for 30-40min, reducing the temperature of the solution to 40--45 C , dropping 1.89-1.91mol a -bromo propanamide, refluxed for 9-10h after addition, reducing the temperature of the solution to 3-- 60C, standing for 28-32h, filtered, the precipitated solid was washed with ethyl ether solution, then washed with a saline solution, dehydrated with dehydrating agent, and then recrystallized from triethylamine solution, got a-bromo-2,6-dimethylaniline. |
| priorityDate | 2015-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.