| abstract |
The present invention relates to double stranded RNA constructs comprising a sense and anti-sense strand wherein these constructs show improved tissue and cellular uptake characteristics with improved in vivo delivery properties. These RNAi constructs are preferably self-delivering RNAi compounds of at least 12 contiguous nucleotides such as, sd-rxRNA molecules. These RNAi constructs are used in methods of treating dermal and fibrotic conditions, and in efficient in vivo delivery of RNAi compounds to the skin for gene silencing. |