http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2015274506-C1

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filingDate 2015-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f37e58e38b35917621be0563c6f7ae38
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publicationDate 2022-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AU-2015274506-C1
titleOfInvention Homogenous antibody drug conjugates via enzymatic methods
abstract The present application in one aspect provide Fc-containing polypeptide conjugates comprising an Fc-containing polypeptide conjugated to a conjugate moiety, wherein the Fc- containing polypeptide comprises an N-glycosylated Fc region comprising an acceptor glutamine residue flanked by an N-glycosylation site and wherein the conjugate moiety is conjugated to the Fc-containing polypeptide via the acceptor glutamine residue. Also provided are methods of making such Fc-containing polypeptide conjugates by using a wildtype or engineered transglutaminases. Further provided are engineered transglutaminases specifically designed for carrying out such reactions.
priorityDate 2014-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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