| abstract |
The present invention provides an aptamer that bonds to autotaxin, said aptamer including a nucleotide sequence represented by the formula GWAACAGGUUUUGCU (SEQ ID NO: 42) (in the formula, W is A or U, and uracil can be thymine), and being one of the following: (a) the aptamer, wherein in the nucleotide included in the aptamer, (i) the 2' position of the ribose in each pyrimidine nucleotide is a fluorine atom, and (ii) the 2' position of the ribose in each purine nucleotide is a hydroxy group; or (b) the aptamer from (a), wherein (i) the fluorine atoms at the 2' position of the ribose in each pyrimidine nucleotide are each independently unsubstituted or substituted with an atom or a group selected from the group consisting of a hydrogen atom, a hydroxy group, and a methoxy group, and (ii) the hydroxy groups at the 2' position of the ribose in each purine nucleotide are each independently unsubstituted or substituted with an atom or a group selected from the group consisting of a hydrogen atom, a methoxy group and a fluorine atom. |