| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e7dce1d8014f425fb999a534750dbbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66e061087b8b0ca4bda35df8e395be73 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-20 |
| filingDate |
2015-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_634e656ea437d373cc103eb5c4a4fe98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1b58aec2b6b193bd468537fa1842c8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e396a0cecb636b815518fe6d1415e0d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c1523fe26ef5c5b97c4a343ec9c8af8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60dd8aaff8abfc8b3ec15ef0968b73a6 |
| publicationDate |
2015-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2015213355-A1 |
| titleOfInvention |
Avirulent, immunogenic flavivirus chimeras |
| abstract |
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural protein genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019068876-A1 |
| priorityDate |
2000-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |