| abstract |
H:\dxjrntvoveroaRPorthl\DCC\RBR\7350455_Ldocx:-8/01/2015 Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of 5 a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions 10 comprising a sirtuin-modulating compound in combination with another therapeutic agent. |