| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b81a5eda0046acaa7b584105a93cd52 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate |
2014-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eacf61abb7dacbbe9eb891183380f0af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_834fad1d5a503e90c85e693d815f6d5c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_089041a8a9c4295a60ba02c26acdedc6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3be22764960e5d5d5109c20f9775518
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fac2f3775218f535609ca1b54a8cc21c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de44fc5b4f4c24b459ff855e73e0b0b0 |
| publicationDate |
2018-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2014306021-B2 |
| titleOfInvention |
Polyconjugates for delivery of RNAi triggers to tumor cells in vivo |
| abstract |
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand- targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger. |
| priorityDate |
2013-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |