| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fb38ebd40c70e97cc5f1519c6699162 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 |
| filingDate |
2014-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_061055c3c95bf118076c9d46336c7ae6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbffd0ac6ded257c10fe30b42451fd78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af9b0d7a045a13f8923a438798f39cf1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c3928ae5296d637273635f5f1792d8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9d77437ea726dba295d4d2140c2d96b |
| publicationDate |
2017-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2014253584-B2 |
| titleOfInvention |
Vinca Alkaloid Derivatives, Preparation Method therefor and Application thereof |
| abstract |
The present invention provides a new kind of vinblastine derivatives, preparation method therefor and application thereof. The vinblastine derivatives comprise hydrazinolyzed vinblastine compounds and vinblastine dipeptide derivatives. The hydrazinolyzed vinblastine compounds are compounds obtained from the reaction of the vinblastine compounds or salts thereof with hydrazine hydrate; the vinblastine dipeptide derivatives are compounds obtained from the condensation of hydrazinolyzed vinblastine compounds with N-benzyloxycarbonylglycyl-proline. The present invention provides the application of vinblastine derivatives or the pharmaceutical composition thereof in anti-tumor, preventing or treating diabetic retinopathy, rheumatoid arthritis and serving as angiogenesis inhibitor or vascular disrupting agent. |
| priorityDate |
2013-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |