http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2014240375-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a37a7b77478131e22b6a4f468419b9c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-075 |
| filingDate | 2014-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4f9454e604f354fb22357e89b4d4134 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1c2b6b8926155bb29c5c51cc1e21703 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a79ab68f9f2eda9b42e98955f70bd90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f346129d40fe39f1b61f43fc8f2f310a |
| publicationDate | 2017-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2014240375-B2 |
| titleOfInvention | Patient-specific stem cell lines derived from human parthenogenetic blastocysts |
| abstract | Methods are disclosed for generating HLA homozygous parthenogenetic human stem cell (hpSC-Hhom) lines from both HLA homozygous and HLA heterozygous donors. These hpSC Hhom lines demonstrate typical human embryonic stem cell morphology, expressing appropriate stem cell markers and possessing high levels of alkaline phosphatase and telomerase activity. Additionally, injection of these cell lines into immunodeficient animals leads to teratoma formation. Furthermore, in the case of HLA heterozygous donors, the hpSC-Hhom lines inherit the haplotype from only one of the donor's parents. SNP data analysis suggests that hpSC-Hhom lines derived from HLA heterozygous oocyte donors are homozygous throughout the genome as assessed by single-nucleotide polymorphism (SNP) analysis. The protocol as disclosed minimizes the use of animal-derived components, which makes the stem cells more practical for clinical application. |
| priorityDate | 2007-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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