http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2014202009-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f79749e86afce9444a364ab60ca3584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ccd6c30c71e83eb4f45bab3bd664f52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-36 |
| filingDate | 2014-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e62b7d49fa702f40ae2ebe3aa6f38724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51937435d45c1db1b586978beda8bd98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82ef5b547d544a5b44efe96d492907ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9cefb1367a118e034d04781376b4d4c |
| publicationDate | 2014-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2014202009-A1 |
| titleOfInvention | Anti-factor xi monoclonal antibodies and methods of use thereof |
| abstract | The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain 5 of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives ofthe monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI 10 monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods ofthe invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or 15 treating an acute inflammatory reaction. Methods for making an anti-factor XI monoclonal antibody, or epitope-binding fragments, variants, or derivatives thereof, are also provided. Figure 1 Silicone Rubber Blood Flow (100 mi/min) PPACK Sample (20 puimin) (100 pnin) Collagen Coated ePTFE (4.0 mm i. x 2.0 cm) B ePTFE Collagen Coated 60 sm |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114478781-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110099927-A |
| priorityDate | 2007-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1387.