http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2013288383-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_436c80ac97c18c9be85d896bfe12b8b5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2257 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-78 |
| filingDate | 2013-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_657537be94feb79b144596786a061e4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4843263226c760bbf7cb2b808235bb94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53bc76a13e0d52d902956173df49ec92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_185c22db3a2050c3f3f0246d7f11aa64 |
| publicationDate | 2015-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2013288383-A1 |
| titleOfInvention | Popelova, AndreaLipidated peptides as anti-obesity agents |
| abstract | Lipidated peptides, analogs of both forms of the prolactin-releasing peptide, PrRP31 and PrRP20, represent anorexigenic compounds that lower food intake and function in the brain after peripheral administration. The analogs PrRP31 and PrRP20 lipidated at the N-terminus by myristic or palmitic acids bind with high affinity to the endogenous receptor GPR10 in the rat pituitary cell line RC-4B/C and CHO cell line with transfected human receptor. These lipidated peptides also significantly decrease, in a dose-dependent manner, the food intake in fasted mice and have similar effects in comparable doses as centrally administered natural PrRP31, these effects are, however, stronger and longer lasting. Lipidation of an effective anorexigenic neuropeptide PrRP induces a central effect after peripheral administration and thus makes the lipidated analogs of PrRP a promising anti-obesity drug. |
| priorityDate | 2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 353.