| abstract |
The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are 5 selective for JAKI, JAK2 or JAK3 kinases and combinations thereof such as JAKI and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases. 4895540_1 (GHMatters) P72623.AU.1 |