abstract |
Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying therapeutic agents that binding to HMD2 or a family member of HDM2. See Figure 1. WO 2008/095063 PCT/US2008/052580 B Fmoc . Fnoc-S, -2 ?S,4 10A 2 74% 412o .le $AJ4.5!Z 4 ...- ,Q. IOi 4&Il0 1 SA14.253.7 K ... *- 4 9,I9 o 5 A 4 4 0 3.7 - r e . " 0 .. * 6 _1 Z4)~v~t 7R Q. F i |