http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2013205228-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 |
| filingDate | 2013-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab7febd50721175edde8b820ce920c1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d843b1d0ca02bbde5a397e00f137612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acd662d8472a87e3cd449d0173daab1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fb469608164795f4faae536563d63a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_100937be3a0133b821fa23908a5373d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be64213eeb96f4fd7094d50a52111634 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e13701baf8ac28c1142ffc203522cb28 |
| publicationDate | 2013-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2013205228-A1 |
| titleOfInvention | Identification and method for using the Pre-Ligand assembly domain of the IL-17 receptor |
| abstract | The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-1 7R) family member, wherein the PLAD polypeptide inhibits multimerization of a receptor 5 complex comprising an IL-i 7R family member. Also provided are isolated PLAD-binding polypeptides, e.g., antibodies and avimers, which specifically bind to a PLAD polypeptide described herein. Related chimeric proteins, conjugates, nucleic acids, vectors, and host cells are provided herein. Further provided are methods of treating an inflammatory or autoimmune disease, methods of inhibiting IL- 17-mediated signal transduction, methods of inhibiting IL- 17 10 ligand binding, methods of inhibiting multimerization of IL-1 7R complexes, and methods of inhibiting the production of at least one cytokine, chemokine, matrix metalloproteinase, or other molecule associated with IL- 17 signal transduction are provided. |
| priorityDate | 2007-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1549.