| abstract |
Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w. Figure 1 Compaction Profiles- Pressure Plot --*-Blend A a 3.0 -- Blend B =2.5 U) 0 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 Compaction Pressure (MPa) |