| abstract |
H:\SXD\lnienvoven\NRPortbl\DCC\SXD\5060770_ .doc-4/9/2013 This invention relates to compounds that inhibit El activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia. |