abstract |
H:\fmt\Intenvovcn\NRPottbl\DCC\FM-I4427591_l.doc-6/042013 This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties. |