abstract |
The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula IA or Formula IB shown below, wherein R , Ria, R2, R', Rla, Rlb G, X, Z, Y, and A ED are as defined herein. Ae RI R 1-a Rla RaG Rab (IA) (I)B :kR38.,R3b (mB) Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors. |