http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2012244352-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fac65659bfec1cdbccaa51b16b8b1d59 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 2012-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70f79e0ace8b898fc9cbac380a368da6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2c43b69892c260b8dd591632ada9fde http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ba7e8b96ff12679ce202510f93e04cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39599964f12293099679f35463437d08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c418df8e40abb0bcdb3bf06a1e2d0b07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc6df25f8c3391189593f85f28e3d1d9 |
| publicationDate | 2017-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2012244352-B2 |
| titleOfInvention | Methods and compositions for inhibiting CD32b expressing cells |
| abstract | The invention relates to an immunoglobulin that has (a) enhanced binding affinity to FcgammaRlIb and reduced binding affinity for FcgammaRIIIa relative to a parent antibody; (b) binds FcgammaRlIb with a Kd of less than about 100 nM and (c) coengages a target antigen and FcgammaRlIb on the cell surface. The invention also relates to methods of inhibiting a cell comprising contacting the cell with an immunoglobulin, wherein the immunoglobulin (a) binds FcgammaRlIb with a Kd of less than about 100 nM and coengages a target antigen and FcgammaRlIb on the cell surface; (b) has enhanced binding affinity to FcgammaRlIb and reduced binding affinity for FcgammaRIIIa relative to a parent antibody, and coengages a target antigen and FcgammaRlIb on the cell surface; or (c) has enhanced binding affinity to FcgammaRlIb relative to a parent immunoglobulin, coengages CD19 and FcyRIIb on the cell surface, and wherein the cell is a B-cell. |
| priorityDate | 2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 759.