| abstract |
CANRPorlbl\DCC\MDT\4231874_ .DOC-5it4/2012 IMIDIAZOLE DERIVATIVES AND THEIR USE AS AGONISTS SELECTIVE AT ALPHA 2B OR 2B/2C ADRENERGIC RECEPTORS Abstract A compound having a structure selected from the group consisting of: in which each x is independently (1) or (2); Y is selected from the group consisting of O;S;N;-(C(R 7)z)s where each R7 is independently as previously defined fir R1, each z is independently 1-2, and s is 1-3; CH=; -CH=CH ;or YiCH 2 where Yi is 0, N, or S; and the dotted lines are optional double bonds, with the pviso that if the ring including Y is a cyclohexane ring or a heterocyclic 5 member ring said ring is not fully unsaturated, and that if Y is 0,N or S, the ring including Y contains at least one said double bond, said compound further having selective agonist activity at the a2B or a2B/a2C adrenergic receptor subtype(s) over the a2A adrenergic receptor subtype, and all pharmacologically acceptable salts, esters, stereoisomers and racemic mixtures thereof. |