| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ecf631ba60ae8b9030ffa82318ae99ea |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4725 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78 |
| filingDate |
2011-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a7e454b82637f9274adfe006b3f9c89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0751ab03985ec1a9166ad0b4d33827b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8440c853d2a9ad5b345cd7c79bab9232
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbc8d44a64c687e154c41f51bde7dff3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b2d8d62afc9208617bb6c5c0c0be69a |
| publicationDate |
2015-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2011256256-B2 |
| titleOfInvention |
Biglycan mutants and related therapeutics and methods of use |
| abstract |
The present discloure provides biglycan-related therapeutic polypeptides comprising substitutions at two serine residues such that the polypeptide does not comprise any glycosaminoglycan side chains. Further provided are methods for treating diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, for example, due to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders. |
| priorityDate |
2010-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |