| abstract |
IL -18 BINDING PRO TEINS Abstract The present invention encompasses IL-1 8 binding proteins, particularly antibodies that bind human interleukin- 18 (hIL- 18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hlL-18 and/or that neutralize hIL-1 8 activity in vitro and in vivo. An antibody of the io invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hlL- 18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hlL 18 activity is detrimental. |