http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2011202225-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2e9f5ce8630d9b282043b8d060caff http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ab74fced2e2170de7bad77e731c9b0b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2011-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b0d9ad62c818d9c569f5b57170378a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb1415583fad773e575e5b37df9ede9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3697aa93e443e2aa8dfd09fa1f0180cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5e441ba49ba485263ad1dc2de180315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_425b235722a8edd9fd647915fa027ea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8419fb6b56e29e0b6883d1fed37e13b8 |
| publicationDate | 2015-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2011202225-B2 |
| titleOfInvention | Non-cytotoxic protein conjugates |
| abstract | Non-cytotoxic Protein Conjugates 5 A non-cytotoxic protein conjugate for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell, comprising: (i) a dynorphin Targeting Moiety (TM), wherein said TM is an agonist of a receptor present on said nociceptive sensory afferent cell, and wherein said receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic 1o protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of said nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory is afferent cell. Nucleic acid sequences encoding the protein conjugates, methods of preparing same and uses thereof are also described. |
| priorityDate | 2005-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 367.