http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2010324632-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5670a8f1f070df32157428d3a7ba55be |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-392 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0074 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 |
| filingDate | 2010-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fc81bf993fc34ad8bead82abe2bf599 |
| publicationDate | 2012-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2010324632-A1 |
| titleOfInvention | 6-substituted estradiol derivatives and methods of use |
| abstract | Disclosed are compounds of the formula (I): where in R, R, R and R are independent l y hydrogen, C -C alkyl, halo, a sulfate, a glucuronide, -OH, a bulky group, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, N ( CH ) ; a phosphate group, and a phosphinate group; R is hydrogen, halogen or alkyl; R11 i s selected from the group consisting of H, C -C alkyl, halogen, a sulfate, a glucoronide, - SONH, -COOH, -CN, -CHCN-, -NHCN-, -CHO, =CHOCH, -COO salt, -0S0alkyl, -NH, and -NHCO ( CH ) n; R is selected from the group consisting o f H, a C -C alkyl, a sulfate, a glucoronide, a bulky group, aryl, cycloalkyl, heteroaryl and heterocycloalkyl; X i s selected from the group consisting of C -C alkyl, C -C alkenyl, C -C alkynyl, halogen, a glucoronide, -NH, - SONH, -COOH, -CN, -CHCN, -NHCN, -CHO, -COOsalt, -0S0alkyl, - SH, - SCH, -CH [ ( CH ) CH ] COOCH, - ( CH ) mCOOCH, - ( CH U-O-CH, - ( CH ) m-0- ( CH ) CH, ( CH) - S -CH, - ( CH U- S - ( CH )CH, - ( CH ) -NH- ( CH ) CH, -C -C alkenyl -0- ( CH ) CH, - C -C alkenyl - S - ( CH ) CH, -C -Calkenyl -N- ( CH ) CH, -C -C alkynyl -O- ( CH ) CH, -C -C alkynyl - S - ( CH ) CH, -C-C alkynyl -N- ( CH ) CH, - ( CH U-OH, - ( CH ) -O-NH, - ( CH) - S -NH, -NH ( CH ) CH, -NH ( CH ) OCH, -NH ( CH ) CHOH-COOH, -N ( CH ), - ( CH ) (NH ) CHOH, -NHCOOH, - ( CH ) NHCOOH, -NO, - SCN, - S0alkyl, -B ( OH ) , - ( CH ) N ( CH ) - SO-NH, - ( CH ) -NH- SO -NH,-NHC ( = S) CH, and -NHNH; and Y is selected from hydrogen, =0, -OCO(R) and -OH; wherein m is an integer between 0-20, n is an integer between 0-8, the symbol represents either a single or a double bond capable of forming a keto group at position 3 or 17; and the Λ/WV symbol represents any type of bond regardless of the stereochemistry; and the respective enantiomers, other stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of said compounds. The compounds are useful in the treatment of various types of cancer. |
| priorityDate | 2009-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 520.