| abstract |
USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS Abstract A pharmaceutical composition, comprising a combination of an antibiotically active 5 compound of the formula (I): with a p-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another p-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI). R6 R5 R3 N fR2 |