| abstract |
A novel gene (designated 121 P2A3) and its encoded protein, and variants thereof, are described wherein 121 P2A3 exhibits tissue specific in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 121 P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121 P2A3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P2A3 can be used in active or passive immunization. |