| abstract |
Disclosed is a milk protein fraction having the characteristic properties (1) to (4) shown below, which has an excellent inhibitory activity on bone resorption and is therefore useful for the prevention or treatment of a bone disease: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction that contains a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) in the constituent amino acid composition of the milk protein fraction, the basic amino acid content is 18 to 20 wt%, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) [basic amino acid(s)/acidic amino acid(s)] is 0.7 to 0.9; and (4) the milk protein fraction has an activity of inhibiting bone resorption. |