http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2008270020-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 |
| filingDate | 2008-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d96e4998d4ebedaa048c65293bc0e93e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8d45d5977eaff7d3568e5efcb35e42e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_822058bc991fba47dffbd0e74d5acaa7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dc1c588a38c6968b237293fbeb0e0ad |
| publicationDate | 2013-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2008270020-B2 |
| titleOfInvention | Plasmid-encoded neurotoxin genes in clostridium botulinum serotype A subtypes |
| abstract | The present invention provides a novel isolated plasmid, wherein the plasmid is a native plasmid found in unique C. botulinum type A strains and encode either BoNT/ A3 or BoNT/ A4 and BoNT/B. The present invention also provides a method of obtaining a plasmid-encoded botulinum neurotoxin and botulinum neurotoxin complex comprising the step of isolating a plasmid encoding the cntA/A or cntA/B neurotoxin gene and genes encoding protein components of the toxin complex from a C. botulinum type A strain. The inventors performed comparative analyses of representative BoNT/A subtype strains by pulsed-field gel electrophoresis (PFGE) and Southern hybridizations with probes specific for the BoNT/A and B genes, cntA/A and cntA/B. Unexpectedly, the inventors determined that the genes encoding BoNT/ A3 in the A3 strain, and BoNT/ A4 and BoNT/B in the A4 strain, are on plasmids. |
| priorityDate | 2007-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.