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filingDate 2008-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a16ec695d7bfaf837a7c1f795ceea42
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publicationDate 2013-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AU-2008241528-B2
titleOfInvention Novel opiate reduction utilizing catalytic hydrogen transfer reaction
abstract An improved opiate synthesis scheme is provided. An improvement to the oxidation of oripavine and oripavine derivatives comprises the in-situ formation of the peroxacids required to oxidize the oripavine and oripavine derivatives to form an intermediate. An improvement to the reduction of the intermediate to form oxycodone and oxycodone derivatives comprises reduction utilizing a hydrogen transfer reagent. These improvements allow the production of oxycodone and oxycodone derivatives without isolation of the intermediate, providing a one-pot synthesis method.
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