| abstract |
Abstract The invention relates to an apolipoprotein construct, an apolipoprotein construct for use as a medicament, a nucleic acid sequence encoding the apolipoprotein construct, a vector comprising the nucleic acid sequence, a method for producing the 5 apolipoprotein construct, and use of the apolipoprotein construct for the preparation of a pharmaceutical composition. The presented data document that the constructs according to the invention are capable of binding lipids, are capable of binding cubilin, which is a strong Apo Al receptor, stronger than native Apo A-1 and that the plasma half life of the constructs is at least tripled compared to native Apo A-1. 10 Together these data document that the constructs according to the invention are strong candidates for treatment of cardiovascular diseases. |