http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2008200842-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2008-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65602cde63a0a33ae346355a46e4aaf7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1ae03b40e03cba63ad4d15661aeeaba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b93b047de7e4c1f3f7d8556008d0db2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2625bd806ae442524655d9cfe43797b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d90cebb90200c3f0773e9bd9935499dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_671158dd1e0ab84430364984a3b3aa59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6b38ba86862f3b24f6204a248494f1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e257bbdc5b38b8182f1899a52a00d3d |
| publicationDate | 2011-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2008200842-B2 |
| titleOfInvention | Tricyclic thrombin receptor antagonists |
| abstract | Heterocyclic-substituted tricyclics of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: 5 the dotted line represents an optional single bond; ----- represents an optional double bond; n is 0-2; Q is cycloalkyl, optionally substituted by R'3 and R14 ; each R" is independently selected from H, (C,-C6 )alkyl, (03 -C5 )cycloalkyl, 10 -(CH 2)neNHC(O)OR'*O, -(CH 2)neNHC(O)R'", -(CH 2),,6NHC(O)NR 4 R5, -(CH 2)neNHSO 2 R0 , -(CH 2)n6 NH S0 2N R4R, and -(CH 2)nsC(O)NR 28 R29 where ne is 0-4, haloalkyl, and halogen; each R14 is independently selected from H, (C,-C)alkyl, -OH, (C-C)alkoxy, R27-aryl(C1-C5)alkyl, heteroaryl, heteroarylalkyl, heterocycyl, is heterocycylalkyl, -(CH 2)n6NHC(O)OR'b, -(CH2)neNHC(O)R'Ib, -(CH 2)neNHC(O)NR 4R5, -(CH 2)meNHSO 2 R, -(CH 2)n6NHSO 2NR4R5 , and -(CH 2)neC(O)NRaR" where n, is 0-4, halogen and haloalkyl; or R's and R14 taken together form a spirocyclic or a heterospirocyclic ring of 3-6 atoms; 20 wherein at least one of R'5 or R" is selected from the group consisting of -(CH 2)neNHC(O)OR"", -(CH 2)neNHC(O) R'O, -(CH 2)neNHC(O)NR 4R', -(CH2)sNHSO 2 R'6 , -(CH 2),nNHSO 2NRR 6, and -(CH 2)neC(O)NR 2 R29 where na is 04; Het is a mono- or bi-cyclic optionally substituted heteroaryl group; and 25 B is a bond, alkylene, or optionally substituted alkenylene or alkynylene, wherein the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. 30 Combination therapy with other cardiovascular agents is also claimed. y- R .3 10 (CH 2)n, R x R R Q (I) Het |
| priorityDate | 2002-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 187.