http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2006250294-B9
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17a67d9c7d87b4a9ab0acc66ec3eb524 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-90245 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5032 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate | 2006-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a306651fcd52a1321ad8e194cedcd6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02ea4199ed709e74f0a01395d1559091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_763d1189ee5be74a923cc4ef8390f6d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64ed667860a0310c6cc3c74a00cc436c |
| publicationDate | 2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2006250294-B9 |
| titleOfInvention | Inhibitors of PGHS-2 transactivator activity |
| abstract | Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-κB regions of the promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity. |
| priorityDate | 2005-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 513.