abstract |
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R is hydroxy or hydrogen; R is hydroxy; methoxy or hydrogen; provided that at least one of R and R is hydroxy; R is selected from hydrogen; halogen; cyano; optionally substituted Chydrocarbyl and optionally substituted Chydrocarbyloxy; R4 is selected from hydrogen; a group -(O)n-R where n is 0 or 1 and R is an optionally substituted acyclic Chydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C hydrocarbyl- amino; or R and R together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NRR forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors. |