http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2005286833-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1835e02861a323ebe33e2c2f2241f45d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2005-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9e4b26f7ddb7c27013eec04b007b03f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_490f7be010d66465bf6575f458419138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abc82dc1d1a75d3ce4ef7b86f0d967f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75f6c9d5d5b23135b6d43d861989cdc3 |
| publicationDate | 2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2005286833-B2 |
| titleOfInvention | Sulfonyl hydrazines as hypoxia-selective antineoplastic agents |
| abstract | Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formulas (I), (II), (III) and (IV). Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates and metabolites from all stages. The aforementioned prodrugs are preferentially activated in hypoxic tumors and can be given either alone, or in combination with other anticancer agents or with phototheraphy or radiotherapy. Where R = Calkyl, or Chaloalkyl (preferably containing no more than 5 halogen groups, preferably 2-chloroethyl); R' and R" are independently C alkyl, or C aryl or heteroaryl (preferably methyl); R is H, C alkyl, C alkoxyl, C aryl or heteroaryl or C aroxyl or heteroaroxyl (preferably methyl and ethyl); X is O, NH, or NR (preferably O); Y is (CH) , where n = 1, 2, 3, 4 or 5 (preferably n = 2 and 3); or Y = aryl or heteroaryl (preferably para-phenyl); A = CH, or N (preferably CH); and B = CH=CH, O, S, NH, or NR (preferably CH=CH); or pharmaceutically acceptable salts, solvates, polymorphs or metabolites, thereof. |
| priorityDate | 2004-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 305.