| abstract |
The invention concerns amino-tropane derivatives of general formula (I), wherein: R R et R represent hydrogen atoms or alkyl groups; R represents a hydrogen atom or an alkyl, cycloalkyl, heterocycloalkyl or aryl group; R represents a group of formula -(CH)-(CO)-Y or -(CO)-(CH)-Y, wherein Y represents a hydrogen atom or a hydroxy, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl group or NRR; R represents 1 to 3 groups selected among halogen atoms and alkyl, cycloalkyl OR, -NRR', -CO-NRR', -NR-CO-R', -NR-CO-NRR', -NR-COOR', -NO, -CN and -COOR groups; R is selected among a group of formula (a), (b), (c) or (d): or a group of formula -A-R, -A-CH=N-R, -A-N(R)-A'-R, -A-CO-N(R)-A'-R, -A-CH(NH)-R, -A-N(R)-COO-A' or -(CH)r-heteroaryl. The invention also concerns a method for preparing said derivatives and the therapeutic use thereof. |